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IgG N-糖基心血管年龄独立于真实年龄精准表征心血管事件风险 Article
武志远, 郭政, 郑雨露, 王玉涛, 张海平, 潘慧颖, 李志伟, Lois Balmer, 李霞, 陶丽新, 郭秀花, 王嵬
《工程（英文）》 2023年 第26卷 第7期 页码 99-107 doi: 10.1016/j.eng.2022.12.004
人类蛋白质N-糖基化的十二年全基因组关联研究 Review
Anna Timoshchuk, Sodbo Sharapov, Yurii S. Aulchenko
《工程（英文）》 2023年 第26卷 第7期 页码 17-31 doi: 10.1016/j.eng.2023.03.013
Most human-secreted and membrane-bound proteins have covalently attached oligosaccharide chains, or glycans. Glycosylation influences the physical and chemical properties of proteins, as well as their biological functions. Unsurprisingly, alterations in protein glycosylation have been implicated in a growing number of human diseases, and glycans are increasingly being considered as potential therapeutic targets, an essential part of therapeutics, and biomarkers. Although glycosylation pathways are biochemically well-studied, little is known about the networks of genes that guide the cell- and tissue-specific regulation of these biochemical reactions in humans in vivo. The lack of a detailed understanding of the mechanisms regulating glycome variation and linking the glycome to human health and disease is slowing progress in clinical applications of human glycobiology. Two of the tools that can provide much sought-after knowledge of human in vivo glycobiology are human genetics and genomics, which offer a powerful data-driven agnostic approach for dissecting the biology of complex traits. This review summarizes the current state of human populational glycogenomics. In Section 1, we provide a brief overview of the N-glycan's structural organization, and in Section 2, we give a description of the major blood plasma glycoproteins. Next, in Section 3, we summarize, systemize, and generalize the results from current N-glycosylation genome-wide association studies (GWASs) that provide novel knowledge of the genetic regulation of the populational variation of glycosylation. Until now, such studies have been limited to an analysis of the human blood plasma N-glycome and the N-glycosylation of immunoglobulin G and transferrin. While these three glycomes make up a rather limited set compared with the enormous multitude of glycomes of different tissues and glycoproteins, the study of these three does allow for powerful analysis and generalization. Finally, in Section 4, we turn to genes in the established loci, paying particular attention to genes with strong support in Section 5. At the end of the review, in Sections 6 and 7, we describe special cases of interest in light of new discoveries, focusing on possible mechanisms of action and biological targets of genetic variation that have been implicated in human protein N-glycosylation.
纪学芹,丁莉莉,锁耀宇,史瑞仙,刘燕翔,陈耀平
《中国工程科学》 2015年 第17卷 第6期 页码 77-81
建立宁夏地区妊娠中期胎儿心血管系统各解剖结构内径的正常参考值范围，探求其随孕周变化规律。胎儿心脏各房室及大血管内径随孕周增加而增大，与孕周显著相关（P<0.05）。建立宁夏地区妊娠中期胎儿心血管系统结构相关的正常参考值范围，可评价胎儿心血管系统发育情况，为准确识别胎儿先天性心脏病提供重要依据。
免疫球蛋白G N-糖基化与代谢特征之间的双向因果关联——一项孟德尔随机化研究 Article
孟晓妮, 曹维杰, 刘迪, Isinta Elijah Maranga, 邢薇佳, 侯海峰, 徐希柱, 宋曼殳, 王友信
《工程（英文）》 2023年 第26卷 第7期 页码 74-88 doi: 10.1016/j.eng.2022.11.004
既往研究已发现免疫球蛋白 G（immunoglobulin G, IgG）N-糖基化与代谢特征之间存在关联，但它们之间是否存在因果关联尚有待研究在正向MR分析中，通过整合IgG N-糖基-QTL遗传变异与GWAS 数据和代谢特征进行分析，分别发现59个包括影响体质指数（body mass index, BMI）的9个IgG N-糖基（glycanpeaks, GP）（GP1和GP6等）和影响空腹血糖（fasting plasma glucose, FPG）的 7个IgG N-糖基（GP1和GP5等）以及15个[包括影响BMI 的5个IgG N--糖基（GP2 和 GP11 等）和影响FPG的 4个IgG N-糖基（GP1和GP10等）]由遗传决定的 IgG N-糖基在单样本和两样本MR研究中与代谢特征存在因果关联（全部 P综上所述，本研究全面的双向MR分析提供了IgG N-糖基化与代谢特征之间双向因果关联的证据，在一定程度上揭示了 IgG N-糖基化与代谢特征之间的生物学机制。
第三届中国心血管材料学术大会（The 3rd China conference on cardiovascular materials）
会议日期： 2019年11月23日
会议地点： 中国/广东/深圳
主办单位： 中国生物材料学会心血管材料分会
月经周期中免疫球蛋白G N-糖基化的周期性变化 Article
Julija Jurić, Hongli Peng, Manshu Song, Frano Vučković, Jelena Šimunović, Irena Trbojević-Akmačić, Youxin Wang, Jiaonan Liu, Qing Gao, Hao Wang, Qiaoyun Chu, Marija Pezer, Wei Wang, Gordan Lauc
《工程（英文）》 2023年 第26卷 第7期 页码 108-118 doi: 10.1016/j.eng.2022.10.020
Immunoglobulin G (IgG) is the most abundant plasma glycoprotein and a prominent humoral immune mediator. Glycan composition affects the affinity of IgG to ligands and consequent immune responses. The modification of IgG N-glycosylation is considered to be one of the various mechanisms by which sex hormones modulate the immune system. Although the menstrual cycle is the central sex hormone-related physiological process in most women of reproductive age, IgG N-glycosylation dynamics during the menstrual cycle have not yet been investigated. To fill this gap, we profiled the plasma IgG N-glycans of 70 healthy premenopausal women at 12 time points during their menstrual cycles (every 7 days for 3 months) using hydrophilic interaction ultra-performance liquid chromatography (HILIC-UPLC). We observed cyclic periodic changes in the N-glycosylation of IgG in association with the menstrual cycle phase and sex hormone concentration in plasma. On the integrated cohort level, the modeled average menstrual cycle effect on the abundance of IgG N-glycosylation traits was low for each trait, with the highest being 1.1% for agalactosylated N-glycans. However, intrapersonal changes were relatively high in some cases; for example, the largest difference between theminimum and maximum values during themenstrual cycle was up to 21% for sialylated N-glycans. Across all measurements, the menstrual cycle phase could explain up to 0.72% of the variation in the abundance of a single IgG glycosylation trait of monogalactosylation. In contrast, up to 99% of the variation in the abundance of digalactosylation could be attributed to interpersonal differences in IgG N-glycosylation. In conclusion, the average extent of changes in the IgG N-glycopattern that occur during the menstrual cycle is small; thus, the IgG N-glycoprofiling of women in large sample-size studies can be performed regardless of menstrual cycle phase.
糖尿病前期成年人综合健康生活方式与糖尿病、心血管疾病、癌症和死亡的关联——中美英四队列研究 Article
涂周正, 卢琪, 张言博, 舒哲, 赖雨薇, 马梦男, 夏鹏飞, 耿婷婷, 陈俊祥, 李越, 吴林晶, 欧阳静, 戎志, 丁雄, 韩旭, 陈朔华, 何美安, 张晓敏, 刘烈刚, 邬堂春, 吴寿岭, 刘刚, 潘安
《工程（英文）》 2023年 第22卷 第3期 页码 141-148 doi: 10.1016/j.eng.2022.04.010
2型糖尿病患者的身体活动、久坐行为与心血管疾病患病风险的关系——MIDiab研究 Article
武亚飞, 秦贵军, 王桂侠, 刘礼斌, 陈兵, 管庆波, 袁中尚, 侯旭, 高聆, 徐潮, 张海清, 张栩, 李秋, 宋勇峰, 景斐, 马世瞻, 邵珊珊, 赵萌, 郭庆玲, 童南伟, 赵红燕, 谢晓敏, 刘超, 单忠艳, 成志锋, 余学峰, 陈述林, 杨涛, 王颜刚, 李冬梅, 闫朝丽, 郭立新, 姬秋和, 王文绢, 赵家军
《工程（英文）》 2023年 第20卷 第1期 页码 26-35 doi: 10.1016/j.eng.2022.05.013
转录因子HNF1A、HNF4A和FOXA2调节肝细胞蛋白质N-糖基化 Article
Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš
《工程（英文）》 2024年 第32卷 第1期 页码 58-69 doi: 10.1016/j.eng.2023.09.019
Hepatocyte nuclear factor 1 alpha (HNF1A), hepatocyte nuclear factor 4 alpha (HNF4A), and forkhead box protein A2 (FOXA2) are key transcription factors that regulate a complex gene network in the liver, creating a regulatory transcriptional loop. The Encode and ChIP-Atlas databases identify the recognition sites of these transcription factors in many glycosyltransferase genes. Our in silico analysis of HNF1A, HNF4A, and FOXA2 binding to the 10 candidate glyco-genes studied in this work confirms a significant enrichment of these transcription factors specifically in the liver. Our previous studies identified HNF1A as a master regulator of fucosylation, glycan branching, and galactosylation of plasma glycoproteins. Here, we aimed to functionally validate the role of the three transcription factors on downstream glyco-gene transcriptional expression and the possible effect on glycan phenotype. We used the state-of-the-art clustered regularly interspaced short palindromic repeats/dead Cas9 (CRISPR/dCas9) molecular tool for the downregulation of the HNF1A, HNF4A, and FOXA2 genes in HepG2 cells—a human liver cancer cell line. The results show that the downregulation of all three genes individually and in pairs affects the transcriptional activity of many glyco-genes, although downregulation of glyco-genes was not always followed by an unambiguous change in the corresponding glycan structures. The effect is better seen as an overall change in the total HepG2 N-glycome, primarily due to the extension of biantennary glycans. We propose an alternative way to evaluate the N-glycome composition via estimating the overall complexity of the glycome by quantifying the number of monomers in each glycan structure. We also propose a model showing feedback loops with the mutual activation of HNF1A–FOXA2 and HNF4A–FOXA2 affecting glyco-genes and protein glycosylation in HepG2 cells.
关键词： Clustered regularly interspaced short palindromic repeats/dead Cas9 (CRISPR/dCas9) Epigenetics Hepatocyte nuclear factor 1 alpha (HNF1A) Hepatocyte nuclear factor 4 alpha (HNF4A) Forkhead box protein A2 (FOXA2) N-glycosylation HepG2 cells
Estimating the effect of urease inhibitor on rice yield based on NDVI at key growth stages
Kailou LIU,Yazhen LI,Huiwen HU
《农业科学与工程前沿（英文）》 2014年 第1卷 第2期 页码 150-157 doi: 10.15302/J-FASE-2014028
关键词： normalized difference vegetation index (NDVI) N-(n-butyl) thiophosphoric triamide (NBPT) rice grain yield
标题 作者 时间 类型 操作
IgG N-糖基心血管年龄独立于真实年龄精准表征心血管事件风险
武志远, 郭政, 郑雨露, 王玉涛, 张海平, 潘慧颖, 李志伟, Lois Balmer, 李霞, 陶丽新, 郭秀花, 王嵬
期刊论文
免疫球蛋白G N-糖基化与代谢特征之间的双向因果关联——一项孟德尔随机化研究
孟晓妮, 曹维杰, 刘迪, Isinta Elijah Maranga, 邢薇佳, 侯海峰, 徐希柱, 宋曼殳, 王友信
期刊论文
第三届中国心血管材料学术大会（The 3rd China conference on cardiovascular materials）
2019年11月23日
会议信息
第十二届海峡两岸心血管科学研讨会
2019年09月19日
会议信息
月经周期中免疫球蛋白G N-糖基化的周期性变化
Julija Jurić, Hongli Peng, Manshu Song, Frano Vučković, Jelena Šimunović, Irena Trbojević-Akmačić, Youxin Wang, Jiaonan Liu, Qing Gao, Hao Wang, Qiaoyun Chu, Marija Pezer, Wei Wang, Gordan Lauc
期刊论文
糖尿病前期成年人综合健康生活方式与糖尿病、心血管疾病、癌症和死亡的关联——中美英四队列研究
涂周正, 卢琪, 张言博, 舒哲, 赖雨薇, 马梦男, 夏鹏飞, 耿婷婷, 陈俊祥, 李越, 吴林晶, 欧阳静, 戎志, 丁雄, 韩旭, 陈朔华, 何美安, 张晓敏, 刘烈刚, 邬堂春, 吴寿岭, 刘刚, 潘安
期刊论文
2型糖尿病患者的身体活动、久坐行为与心血管疾病患病风险的关系——MIDiab研究
武亚飞, 秦贵军, 王桂侠, 刘礼斌, 陈兵, 管庆波, 袁中尚, 侯旭, 高聆, 徐潮, 张海清, 张栩, 李秋, 宋勇峰, 景斐, 马世瞻, 邵珊珊, 赵萌, 郭庆玲, 童南伟, 赵红燕, 谢晓敏, 刘超, 单忠艳, 成志锋, 余学峰, 陈述林, 杨涛, 王颜刚, 李冬梅, 闫朝丽, 郭立新, 姬秋和, 王文绢, 赵家军
期刊论文
转录因子HNF1A、HNF4A和FOXA2调节肝细胞蛋白质N-糖基化
Vedrana Vičić Bočkor,Nika Foglar,Goran Josipović,Marija Klasić,Ana Vujić,Branimir Plavša,Toma Keser,Samira Smajlović,Aleksandar Vojta,Vlatka Zoldoš
期刊论文
陈连民：肠道微生物与心血管代谢健康及精准用药（2022年12月31日）
2023年02月27日
会议视频
Estimating the effect of urease inhibitor on rice yield based on NDVI at key growth stages
Kailou LIU,Yazhen LI,Huiwen HU
期刊论文
赵家军：2型糖尿病患者的身体活动、久坐行为与心血管疾病风险的关系：MlDiab研究（2023年2月21日）
2023年03月02日
会议视频
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